BO IS COMPLETELY CLEAR

OF ALL OF THE FOLLOWING

Genetically based Diseases!

Total of over 170 diseases

BO

 MOYEN SIZED PUREBRED POODLE

Bo's Mom

Excellent OFA Hips

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Bo's Dad

Excellent OFA Hips

BO'S PARENTS

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​Von Willebrand Disease Type I (VWF) BLOOD

Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding dur…

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Seen in Poodle (Standard)s, Poodle (Small)s, but not Lakeshore's Intricate Details.

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Congenital Macrothrombocytopenia (TUBB1 Exon 1, Cavalier King Charles Spaniel Variant) BLOOD

This is a benign disorder of platelet production that leads to abnormally large, sparse platelets. Affected dogs typically do not suffer any ill effects from the size or …

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Seen in Poodle (Standard)s, Poodle (Small)s, but not Lakeshore's Intricate Details.

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Progressive Retinal Atrophy - prcd Progressive rod-cone degeneration (PRCD Exon 1) EYES

This retinal disease causes progressive, non-painful vision loss. The retina contains the cells, photoreceptors, that collect information about light: that is, they are t…

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Seen in Poodle (Standard)s, Poodle (Small)s, but not Lakeshore's Intricate Details.

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GM2 Gangliosidosis (HEXB, Poodle Variant) MULTISYSTEM

An early onset form of lysosomal storage disease, this can cause affected dogs to display neurologic signs as puppies or young adults. These include partial or total visi…

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Seen in Poodle (Standard)s, Poodle (Small)s, but not Lakeshore's Intricate Details.

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Degenerative Myelopathy (SOD1A) BRAIN AND SPINAL CORD

A disease of mature dogs, this is a progressive degenerative disorder of the spinal cord that can cause muscle wasting and gait abnormalities. Affected dogs do not usuall…

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Seen in Poodle (Standard)s, Poodle (Small)s, but not Lakeshore's Intricate Details.

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Neonatal Encephalopathy with Seizures (NEWS) (ATF2) BRAIN AND SPINAL CORD

A neurologic disease of puppies, affected puppies are often smaller than their unaffected littermates and require intensive nursing care. Without this extra support, pupp…

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Seen in Poodle (Standard)s, Poodle (Small)s, but not Lakeshore's Intricate Details.

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Osteochondrodysplasia, Skeletal Dwarfism (SLC13A1) SKELETAL

A form of skeletal dwarfism, this causes affected dogs to have abnormally short legs but a normal sized body due to abnormal fetal skeletal maturation. As a fetus, most o…

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Seen in Poodle (Standard)s, Poodle (Small)s, but not Lakeshore's Intricate Details.

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MDR1 Drug Sensitivity (MDR1)

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with mutations in the MDR1 gene. Symptoms can range from vomiting and diarrhea to lethargy, seizures, or coma. MDR1 mutations are particularly common in herding breeds including Australian Shepherds, Collies, and Border Collies, though many other dog breeds are affected. Please note that the dosage of problem drugs in commercially available heartworm, flea, and tick preventatives should not cause symptoms in MDR1 dogs.

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ALL GENETICALLY BASED BLOOD ISSUES

• P2Y12 Receptor Platelet Disorder (P2RY12)

• Factor IX Deficiency, Hemophilia B (F9 Exon 7, Terrier Variant)

• Factor IX Deficiency, Hemophilia B (F9 Exon 7, Rhodesian Ridgeback Variant)

• Factor VII Deficiency (F7 Exon 5)

• Factor VIII Deficiency, Hemophilia A (F8 Exon 10, Boxer Variant)

• Factor VIII Deficiency, Hemophilia A (F8 Exon 11, Shepherd Variant 1)

• Factor VIII Deficiency, Hemophilia A (F8 Exon 1, Shepherd Variant 2)

• Thrombopathia (RASGRP2 Exon 5, Basset Hound Variant)

• Thrombopathia (RASGRP2 Exon 8)

• Thrombopathia (RASGRP2 Exon 5, American Eskimo Dog Variant)

• Von Willebrand Disease Type III (VWF Exon 4)

• Von Willebrand Disease Type I (VWF)

• Von Willebrand Disease Type II (VWF)

• Canine Leukocyte Adhesion Deficiency Type III (LAD3) (FERMT3)

• Congenital Macrothrombocytopenia (TUBB1 Exon 1, Cavalier King Charles Spaniel Variant)

• Canine Elliptocytosis (SPTB Exon 30)

• Cyclic Neutropenia, Gray Collie Syndrome (AP3B1 Exon 20)

• Glanzmann's Thrombasthenia Type I (ITGA2B Exon 12)

• May-Hegglin Anomaly (MYH9)

• Prekallikrein Deficiency (KLKB1 Exon 8)

• Pyruvate Kinase Deficiency (PKLR Exon 5)

• Pyruvate Kinase Deficiency (PKLR Exon 7 Labrador Variant)

• Pyruvate Kinase Deficiency (PKLR Exon 7 Pug Variant

• Pyruvate Kinase Deficiency (PKLR Exon 7 Beagle Variant

• Pyruvate Kinase Deficiency (PKLR Exon 10)

• Trapped Neutrophil Syndrome (VPS13B)

• Ligneous Membranitis (PLG)

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ALL GENETICALLY BASED HORMONE ISSUES

• Congenital Hypothyroidism (TPO, Tenterfield Terrier Variant)

• Complement 3 (C3) deficiency (C3)

• Severe Combined Immunodeficiency (PRKDC)

• Severe Combined Immunodeficiency (RAG1)

• X-linked Severe Combined Immunodeficiency (IL2RG Variant 1)

• X-linked Severe Combined Immunodeficiency (IL2RG Variant 2)

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ALL IMMUNE CONDITIONS TESTED FOR

• Complement 3 (C3) deficiency (C3)

• Severe Combined Immunodeficiency (PRKDC)

• Severe Combined Immunodeficiency (RAG1)

• X-linked Severe Combined Immunodeficiency (IL2RG Variant 1)

• X-linked Severe Combined Immunodeficiency (IL2RG Variant 2)

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ALL EYE CONDITIONS TESTED FOR

• Progressive Retinal Atrophy - rcd1 Rod-cone dysplasia, rcd1 (PDE6B Exon 21 Irish Setter Variant)

• Progressive Retinal Atrophy Rod-cone dysplasia, rcd1a (PDE6B Exon 21 Sloughi Variant)

• Progressive Retinal Atrophy - rcd3 Rod-cone dysplasia, rcd3 (PDE6A)

• Progressive Retinal Atrophy - CNGA (CNGA1 Exon 9)

• Progressive Retinal Atrophy - prcd Progressive rod-cone degeneration (PRCD Exon 1)

• Progressive Retinal Atrophy (CNGB1)

• Progressive Retinal Atrophy (SAG)

• Golden Retriever Progressive Retinal Atrophy 1 (SLC4A3)

• Golden Retriever Progressive Retinal Atrophy 2 (TTC8)

• Progressive Retinal Atrophy - crd1 (PDE6B)

• Progressive Retinal Atrophy - crd2 (IQCB1)

• Progressive Retinal Atrophy - crd4/cord1 (RPGRIP1)

• Collie Eye Anomaly, Choroidal Hypoplasia (NHEJ1)

• Achromatopsia (CNGA3 Exon 7 German Shepherd Variant)

• Achromatopsia (CNGA3 Exon 7 Labrador Retriever Variant)

• Autosomal Dominant Progressive Retinal Atrophy (RHO)

• Canine Multifocal Retinopathy cmr1 (BEST1 Exon 2)

• Canine Multifocal Retinopathy cmr2 (BEST1 Exon 5)

• Canine Multifocal Retinopathy cmr3 (BEST1 Exon 10 Deletion)

• Canine Multifocal Retinopathy cmr3 (BEST1 Exon 10 SNP)

• Glaucoma Primary Open Angle Glaucoma (ADAMTS10 Exon 9)

• Glaucoma Primary Open Angle Glaucoma (ADAMTS10 Exon 17)

• Glaucoma Primary Open Angle Glaucoma (ADAMTS17 Exon 11)

• Glaucoma Primary Open Angle Glaucoma (ADAMTS17 Exon 2)

• Hereditary Cataracts, Early-Onset Cataracts, Juvenile Cataracts (HSF4 Exon 9 Shepherd Variant)

• Primary Lens Luxation (ADAMTS17)

• Congenital stationary night blindness (RPE65)

• Macular Corneal Dystrophy (MCD) (CHST6)

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Bo is clear of all the Kidney and Bladder conditions that Embark tests for.

• 2,8-Dihydroxyadenine (2,8-DHA) Urolithiasis (APRT)

• Cystinuria Type I-A (SLC3A1)

• Cystinuria Type II-A (SLC3A1)

• Cystinuria Type I-A (SLC7A9)

• Hyperuricosuria and Hyperuricemia or Urolithiasis (SLC2A9)

• Polycystic Kidney Disease (PKD1)

• Primary Hyperoxaluria (AGXT)

• Protein Losing Nephropathy (NPHS1)

• X-Linked Hereditary Nephropathy (Samoyed Variant 2) (COL4A5 Exon 35)

• Autosomal Recessive Hereditary Nephropathy, Familial Nephropathy (COL4A4 Exon 3)

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Bo is clear of all the Multisystem conditions that Embark tests for.

• Primary Ciliary Dyskinesia (CCDC39 Exon 3)

• Congenital Keratoconjunctivitis Sicca and Ichthyosiform Dermatosis (CKCSID), Dry Eye Curly Coat Syndrome (FAM83H Exon 5)

• X-linked Ectodermal Dysplasia, Anhidrotic Ectodermal Dysplasia (EDA Intron 8)

• Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND) (FLCN Exon 7)

• Canine Fucosidosis (FUCA1)

• Glycogen Storage Disease Type II, Pompe's Disease (GAA)

• Glycogen Storage Disease Type Ia, Von Gierke Disease (G6PC)

• Glycogen Storage Disease Type IIIa (GSD IIIa) (AGL)

• Mucopolysaccharidosis Type I (IDUA)

• Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A (SGSH Exon 6 Variant 1)

• Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A (SGSH Exon 6 Variant 2)

• Mucopolysaccharidosis Type VII, Sly Syndrome (GUSB Exon 5)

• Mucopolysaccharidosis Type VII, Sly Syndrome (GUSB Exon 3)

• Glycogen storage disease Type VII, Phosphofructokinase deficiency (PFKM Whippet and English Springer Spaniel Variant)

• Glycogen storage disease Type VII, Phosphofructokinase deficiency (PFKM Wachtelhund Variant)

• Lagotto Storage Disease (ATG4D)

• Neuronal Ceroid Lipofuscinosis 1 (PPT1 Exon 8)

• Neuronal Ceroid Lipofuscinosis 2 (TPP1 Exon 4)

• Neuronal Ceroid Lipofuscinosis 1, Cerebellar Ataxia - NCL-A (ARSG Exon 2

• Neuronal Ceroid Lipofuscinosis 1 (CLN5 Border Collie Variant)

• Neuronal Ceroid Lipofuscinosis 6 (CLN6 Exon 7)

• Neuronal Ceroid Lipofuscinosis 8 (CLN8 English Setter Variant)

• Neuronal Ceroid Lipofuscinosis (MFSD8)

• Neuronal Ceroid Lipofuscinosis (CLN8 Australian Shepherd Variant)

• Neuronal Ceroid Lipofuscinosis 10 (CTSD Exon 5)

• Neuronal Ceroid Lipofuscinosis (CLN5 Golden Retriever Variant)

• Adult-Onset Neuronal Ceroid Lipofuscinosis (ATP13A2)

• GM1 Gangliosidosis (GLB1 Exon 15 Shiba Inu Variant)

• GM1 Gangliosidosis (GLB1 Exon 15 Alaskan Husky Variant)

• GM1 Gangliosidosis (GLB1 Exon 2)

• GM2 Gangliosidosis (HEXB, Poodle Variant)

• GM2 Gangliosidosis (HEXA)

• Globoid Cell Leukodystrophy, Krabbe disease (GALC Exon 5)

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Bo is clear of all the Other Systems conditions that Embark tests for.

• Autosomal Recessive Amelogenesis Imperfecta (Italian Greyhound Variant)

• Persistent Mullerian Duct Syndrome (AMHR2)

• Deafness and Vestibular Syndrome of Dobermans (DVDob, DINGS)

• Shar-Pei Autoinflammatory Disease (SPAID, Shar-Pei Fever) (MTBP)

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Bo is clear of all the Brain and Spinal Cord conditions that Embark tests for.

• Alaskan Husky Encephalopathy, Subacute Necrotizing Encephalomyelopathy (SLC19A3)

• Alexander Disease (GFAP)

• Cerebellar Abiotrophy, Neonatal Cerebellar Cortical Degeneration (SPTBN2)

• Cerebellar Ataxia, Progressive Early-Onset Cerebellar Ataxia (SEL1L)

• Cerebellar Hypoplasia (VLDLR)

• Spinocerebellar Ataxia, Late-Onset Ataxia (CAPN1)

• Spinocerebellar Ataxia with Myokymia and/or Seizures (KCNJ10)

• Benign Familial Juvenile Epilepsy, Remitting Focal Epilepsy (LGI2)

• Degenerative Myelopathy (SOD1A)

• Fetal-Onset Neonatal Neuroaxonal Dystrophy (MFN2)

• Hypomyelination and Tremors (FNIP2)

• Shaking Puppy Syndrome, X-linked Generalized Tremor Syndrome (PLP)

• L-2-Hydroxyglutaricaciduria (L2HGDH)

• Neonatal Encephalopathy with Seizures (NEWS) (ATF2)

• Polyneuropathy, NDRG1 Greyhound Variant (NDRG1 Exon 15)

• Polyneuropathy, NDRG1 Malamute Variant (NDRG1 Exon 4)

• Narcolepsy (HCRTR2 Intron 6)

• Progressive Neuronal Abiotrophy (Canine Multiple System Degeneration) (SERAC1 Exon 15)

• Progressive Neuronal Abiotrophy (Canine Multiple System Degeneration) (SERAC1 Exon 4)

• Juvenile Laryngeal Paralysis and Polyneuropathy, Polyneuropathy with Ocular Abnormalities and Neuronal Vacuolation (POANV) (RAB3GAP1, Rottweiler Variant)

• Hereditary Sensory Autonomic Neuropathy (HSAN), Acral Mutilation Syndrome (GDNF-AS)

• Juvenile-Onset Polyneuropathy, Leonberger Polyneuropathy 1 (LPN1, ARHGEF10)

• Spongy Degeneration with Cerebellar Ataxia 1 (SDCA1), SeSAME/EAST (KCNJ10)

• Spongy Degeneration with Cerebellar Ataxia 2 (SDCA2) (ATP1B2)

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Bo is clear of all the Heart conditions that Embark tests for.

• Dilated Cardiomyopathy (PDK4)

• Long QT Syndrome (KCNQ1)

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Bo is clear of all the Muscular conditions that Embark tests for.

• Muscular Dystrophy Cavalier King Charles Spaniel Variant 1

• Muscular Dystrophy Muscular Dystrophy (DMD Pembroke Welsh Corgi Variant )

• Muscular Dystrophy Muscular Dystrophy (DMD Golden Retriever Variant)

• Centronuclear Myopathy (PTPLA)

• Exercise-Induced Collapse (DNM1)

• Inherited Myopathy of Great Danes (BIN1)

• Myostatin Deficiency, Bully Whippet Syndrome (MSTN)

• Myotonia Congenita (CLCN1 Exon 7)

• Myotonia Congenita (CLCN1 Exon 23)

• Myotubular Myopathy 1, X-linked Myotubular Myopathy (MTM1)

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Bo is clear of all the Metabolic conditions that Embark tests for.

• Hypocatalasia, Acatalasemia (CAT)

• Pyruvate Dehydrogenase Deficiency (PDP1)

• Malignant Hyperthermia (RYR1)

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Bo is clear of all the Gastrointestinal conditions that Embark tests for.

• Imerslund-Grasbeck Syndrome, Selective Cobalamin Malabsorption (CUBN Exon 53)

• Imerslund-Grasbeck Syndrome, Selective Cobalamin Malabsorption (CUBN Exon 8)

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Bo is clear of all the Neuromuscular conditions that Embark tests for.

• Congenital Myasthenic Syndrome (CHAT)

• Congenital Myasthenic Syndrome (COLQ

• Episodic Falling Syndrome (BCAN)

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Bo is clear of all the Skin & Connective Tissues conditions that Embark tests for

• Dystrophic Epidermolysis Bullosa (COL7A1)

• Ectodermal Dysplasia, Skin Fragility Syndrome (PKP1)

• Ichthyosis, Epidermolytic Hyperkeratosis (KRT10)

• Ichthyosis (PNPLA1)

• Ichthyosis (SLC27A4)

• Ichthyosis (NIPAL4)

• Focal Non-Epidermolytic Palmoplantar Keratoderma, Pachyonychia Congenita (KRT16)

• Hereditary Footpad Hyperkeratosis (FAM83G)

• Hereditary Nasal Parakeratosis (SUV39H2)

• Musladin-Lueke Syndrome (ADAMTSL2)

• Clear

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Bo is clear of all the Skeletal conditions that Embark tests for.

• Cleft Lip and/or Cleft Palate (ADAMTS20)

• Hereditary Vitamin D-Resistant Rickets (VDR)

• Oculoskeletal Dysplasia 1, Dwarfism-Retinal Dysplasia (COL9A3, Labrador Retriever)

• Osteogenesis Imperfecta, Brittle Bone Disease (COL1A2)

• Osteogenesis Imperfecta, Brittle Bone Disease (SERPINH1)

• Osteogenesis Imperfecta, Brittle Bone Disease (COL1A1)

• Osteochondrodysplasia, Skeletal Dwarfism (SLC13A1)

• Skeleal Dysplasia 2 (COL11A2)

• Craniomandibular Osteopathy (CMO) (SLC37A2)